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antidepressants and emotional processing about the self

13 January 2020

We want to investigate whether a drug called ‘citalopram’, an antidepressant, changes how the brain deals with emotional and social information about the self and others, in healthy participants. Participants will be randomly assigned to take either citalopram or a placebo tablet, and then asked to complete some questionnaires and cognitive tasks on the computer. You will be asked to complete two sessions, taking approximately 7 hours in total.


  • Age 18-45
  • Fluent in written and spoken English
  • BMI 18-30
  • Not taking any regular medications (except the contraceptive pill)
  • Not experiencing any major medical conditions
  • No history of, or current, significant mental disorder
  • No history of, or current, drug or alcohol dependency
  • Not pregnant or breastfeeding
  • Consume less than 5 cigarettes a day and less than 6 caffeinated drinks per day
  • Not Lactose Intolerant
  • Not taken part in a study using medication within the past 3 months
  • Not allergic or hypersensitive to Citalopram
  • Not taken any recreational drugs in the last 3 months

Take part in this study


Ethical approval

This study has been approved by the University of Oxford Medical Sciences Interdivisional Research Ethics Committee on the 24th September 2019 (R64589/RE002).

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Academic study

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