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Early Versus Delayed Fracture Fixation on Muscle (EFIX)

03 December 2019

Healthy male and female volunteers (aged 18-60 years) needed to take part in a study investigating the effects of ankle fracture on muscle wasting (EFIX study).

The study involves 4 study visits and will include 2 weeks in a lower leg plaster cast, blood samples and calf muscle biopsies.

Inconvenience allowance will be offered to volunteers.


  • Inclusion: Healthy males or females aged 18-60 years
  • Exclusion:
  • 1. Inability to provide informed consent
  • 2. Unable to speak or understand English
  • 3. Patients with diabetes or impaired glucose tolerance,
  • 4. Obese participants (BMI 30+)
  • 5. Smokers
  • 6. Diabetic or arterial non-healing leg/foot ulcers
  • 7. Steroid users
  • 8. Sarcopenic (defined as below 20th percentile for gender and age)
  • 9. Pregnancy
  • 10. Previous personal or family history of venous thromboembolism (blood clot) or clotting abnormalities identified on screening bloods

Take part in this study


Ethical approval

This study has been granted Health Research Authority (HRA) approval (Ref: 18/EM/0404).

About the researcher

This study is sponsored by the University of Nottingham and the individual running the study is a qualified medical doctor and PhD student.

Contact researcher

Academic study

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