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Eclipse Study

03 May 2018

We are testing whether carnitine (a dietary supplement) reduces the liver fat and improves metabolism in individuals who have a high concentration of fat within their liver. Participants will be given either Carnitine or a placebo, together with a meal replacement milkshake twice daily for 6 months.

More detailed information can be obtained from researchers


  • Males
  • 'overweight' or 'obese' (BMI 28-40 kg/m2)
  • Age 18-50 years
  • Non-smokers
  • Having elevated liver fat (measured at the screening visit using abdominal ultrasound)
  • Capable of providing informed consent
  • Non-vegetarian diet (diet includes meat and / or fish)
  • Weekly ethanol consumption <21 units/week
  • Negative for Hepatitis B and C serology, liver autoantibodies, transferrin saturation, α1-antitrypsin levels (measured at the screening visit)
  • No Known history of cardiovascular disease, diabetes mellitus, psychiatric conditions, Chronic kidney disease
  • No Surgery within 6 months prior to start of study
  • No Exposure to drugs known to influence hepatic health (including steroids, statins, omega-3-fatty acids)
  • No Contraindications to magnetic resonance scanning, which includes implanted ferrous material (implantable pacemakers or defibrillators), metallic ocular foreign bodies, ferromagnetic aneurysm clips or severe claustrophobia.

Take part in this study


Ethical approval

Ethics approval has been granted by the Nottingham 2 National Research Ethics Committee (17/EM/0441) and is registered on the clinicaltrials.gov web site (NCT03439917)

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Academic study

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