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How does the inflammatory profile differ between lean and obese people?

09 September 2019

We are looking for lean and obese participants to investigate how the inflammatory profile of stomach fat tissue differs between lean and obese individuals.

The study will involve 3 brief visits to Loughborough University Campus (total time commitment 3 hours).

This will include a screening visit (1 hour), a pre-test visit (30 min) and an experimental visit (1.5 hours). During the experimental visit we will collect a fasted blood sample and a small stomach fat tissue sample via biopsy.

Requirements

  • • Men and women aged 18-40
  • • Lean participants (healthy weight)*: waist circumference ≤94 cm (men) and ≤80 cm (women) and BMI ≥21.0 kg/m2
  • OR
  • Obese participants (increased weight)*: waist circumference ≥102 cm (men) and ≥88 cm (women) or BMI ≥ 30.0 kg/m2
  • *If you are unsure whether you meet the criteria, that’s no problem. We can double check these measurements in the lab.
  • • Engages in less than 60 minutes of moderate to vigorous intensity physical activity per week
  • • Blood pressure systolic blood pressure <160 mmHg and diastolic blood pressure <100 mmHg
  • • Non smoker (including vaping)
  • • No cardiometabolic or inflammatory disease (e.g. heart disease, high blood pressure, type 2 diabetes)
  • • Not taking medication or nutritional supplements (e.g. fish oil/prebiotics) known to interfere with study outcomes (including inflammation, immune function or lipid/carbohydrate metabolism) or prescribed antibiotics within the last 3 months
  • • Stable weight history (less than 3 kg loss or gain in the previous 3 months)
  • • Alcohol consumption less than 28 units for a man or 21 units per week for a woman
  • • Women who are not pregnant or lactating

Take part in this study

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Ethical approval

This study has been reviewed according to procedures specified by the University Research Ethics (Human Participants) Sub-Committee and has been given a favourable opinion for conduct (R19-P144).

About the researcher

Doctorate student in the School of Sport, Exercise and Health Sciences, Loughborough University

Contact researcher

Academic study
 

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