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Minocycline and Depression (MINDEP) study

01 January 1970

There is a growing body of evidence suggesting that inflammation of the brain and central nervous system is linked to multiple mental health issues, including major depressive disorder (MDD). The purpose of this study is to see if adding a course of anti-inflammatory medication (minocycline) or a placebo (sugar pill) alongside a current course of antidepressant treatment (SSRI medications) can help to reduce depressive symptoms in MDD that has not responded treatment with antidepressants alone.


  • - Male or Female aged 25-60
  • - Current diagnosis of Major Depressive Disorder
  • - Are currently taking an antidepressant medication for at least 6 weeks but have still not experienced an improvement in symptoms.
  • - Must not have a known diagnosis of bipolar disorder, psychosis or current substance abuse.

Take part in this study


Ethical approval

Advertisement for use for recruitment of volunteers for study REC Number 15/LO/1907, approved by King’s College Research Ethics Committee. This project contributes to the College's role in conducting research, and teaching research methods. You are under no obligation to reply to this advertisement, however if you choose to, participation in this research is voluntary and you may withdraw at anytime.

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