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The effect of feeding on gut function in lean and obese men (BRAGG Study)

26 October 2018

Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes people remain obese. We are comparing 12 people with obesity with 12 people of normal build, and will look at how quickly food empties out of the stomach and travels through the gut, what the blood flow in the gut is, and also to examine hormones which affect how full people feel after eating.

Requirements

  • 24 healthy male subjects aged 18-60 years; 12 with a BMI 30-40 kg/m2, 12 with a BMI of 20-28 kg/m2 (but waist circumference<96cm)
  • No acute illness in the preceding 6 weeks
  • No use of regular medication
  • No factors which would affect MRI scan (e.g. pace maker, metal clips, metal implants)
  • No history of gastrointestinal motility disorders (eg, gastric reflux disease, irritable bowel syndrome, gastroparesis, sphincter of Oddi dysfunction, etc)
  • No significant previous thoracic or abdominal surgery
  • Active sportsmen and bodybuilders would not be suitable to take part

Take part in this study

Keywords

Ethical approval

This study has been approved by the University of Nottingham Medical School Ethics Committee (reference number; A16042015)

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Academic study
 

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